2026 REVERSAL REPORT

Metabolic Care
in the GLP-1 Era

New evidence for better health that lasts

For decades, obesity treatment focused on one question

How do we
help people
lose weight?
Average GLP-1 weight loss ranges from 8-15%

Their remarkable weight loss

~1 in 5 experience nausea; other side effects include diarrhea, vomiting, and constipation

Side
effects

From boardrooms to curated feeds across the country, GLP-1s quickly dominated national conversation.

Their remarkable weight loss
Average GLP-1 weight loss ranges from 8-15%
Sky-high costs
Employers' drug costs increased up to 200%
Out of pocket prices range from $10,000 to $16,800 annually
Anticipated Business Impact
GLP-1s could save airlines $580m a year
$13 billion boost for apparel
Side 
effects
~1 in 5 experience nausea; other side effects include diarrhea, vomiting, and constipation
Employers' drug costs increased up to 200%
Out of pocket prices range from $10,000 to $16,800 annually

Sky-high costs

GLP-1s could save airlines $580M a year
$13 billion boost for apparel

Anticipated business impact

Everyone tried to pronounce semaglutide

(sem-uh-GLOO-tide)

Millions are embarking on a journey that wasn't available a few years ago, which means millions will come face to face with the next stage: getting the best results and keeping them.

For most people, long-term success hinges on the care and habits that surround the prescription.

Drawing on Virta’s real-world data and over a decade of research, this year’s Reversal Report explores what full metabolic care can look like in the GLP-1 era.